|Adverse drug reactions to cefuroxime axetil are generally mild and transient in nature.The following convention has been used for the classification of frequency:very common (≥1/10), common (≥1/100, <1/10), uncommon (≥1/1000, <1/100), rare (≥1/10,000 and <1/1000), very rare (<1/10,000).|
Infections and infestationsCommon: Candida overgrowth
Blood and lymphatic system disordersCommon: EosinophiliaUncommon: Positive Coombs' test, thrombocytopenia, leukopenia (sometimes profound)Very rare: Haemolytic anaemiaCephalosporins as a class tend to be absorbed onto the surface of red cells membranes and react with antibodies directed against the drug to produce a positive Coombs' test (which can interfere with cross-matching of blood) and very rarely haemolytic anaemia.
Immune system disordersHypersensitivity reactions includingUncommon: Skin rashesRare: Urticaria, pruritusVery rare: Drug fever, serum sickness, anaphylaxis
Nervous system disordersCommon: Headache, dizziness
Gastrointestinal disordersCommon: Gastrointestinal disturbances including diarrhoea, nausea, abdominal painUncommon: VomitingRare: Pseudomembranous colitis
Hepatobiliary disordersCommon: Transient increases of hepatic enzyme levels, [ALT (SGPT), AST (SGOT), LDH]Very rare: Jaundice (predominantly cholestatic), hepatitis
Skin and subcutaneous tissue disordersVery rare: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (exanthematic necrolysis)