Adrenaline (Epinephrine) 1:10,000 Sterile Solution Minijet®
Adrenaline (Epinephrine) 0.1 mg per ml.
Excipient: sodium metabisulfite (E223) 1 mg in 1 ml and total sodium 2.7 mg in 1 ml.
For a full list of excipients, see section 6.1.
Sterile aqueous solution for parenteral administration.
Adjunctive use in the management of cardiac arrest.
In cardiopulmonary resuscitation. Intracardiac puncture and intramyocardial injection of adrenaline may be effective when external cardiac compression and attempts to restore the circulation by electrical defibrillation or use of a pacemaker fail.
Ventricular fibrillation (pulseless ventricular tachycardia)
10ml (1mg) by intravenous injection repeated every 3-5 minutes as necessary.Endotracheal:
20-30ml (2-3mg) via an endotracheal tube, repeated as necessary.Intracardiac injection:
1 to 10ml (0.1 to 1mg), direct into the atrium of the heart.
Intracardiac injection should only be considered if there is no other access available. It should be undertaken by personnel trained in the technique.Children
Initially 0.1ml/kg body weight (10mcg/kg); e.g. 2kg infant would receive 0.2ml of Adrenaline 1:10,000. Subsequent doses should be 1ml/kg (100mcg/kg).Intraosseous:
0.1ml/kg body weight (10mcg/kg).Endotracheal:
A dose has not been established; 10 times the intravenous dose may be appropriate.
10ml (1mg) by intravenous injection repeated every 3-5 minutes as necessary. If there is no response after three cycles, consider injections of adrenaline 5mg.Endotracheal:
20-30 ml (2-3mg) via an endotracheal tube, repeated as necessary.Children
0.1ml/kg initially (10mcg/kg). If no response give 1ml/kg (100mcg/kg). After 3 cycles consider alkalising or antiarrhytmic agents. Intraosseus:
0.1 ml/kg initially (10mcg/kg). If no response give 1ml/kg (100mcg/kg). After 3 cycles consider alkalising or antiarrhythmic agents.
Electromechanical Dissociation (EMD)
10ml (1mg) by intravenous injection repeated every 3-5 minutes as necessary. If normal rhythm does not return after standard measures, consider adrenaline 5mg intravenous.Children
0.1ml/kg initially (10mcg/kg) every 3 minutes, until underlying cause identified. Subsequent doses should be 1ml/kg (100mcg/kg).
Contraindications are relative as this product is intended for use in life-threatening emergencies.
Other than in the emergency situation, the following contraindications should be considered: hyperthyroidism, hypertension, ischaemic heart disease, diabetes mellitus. closed angle glaucoma and hypersensitivity to sympathomimetic amines.
These special warnings and precautions are relative as this product is intended for use in life-threatening situations.
Administer slowly with caution to elderly patients and to patients with ischaemic heart disease, hypertension, diabetes mellitus, hyperthyroidism or psychoneurosis. Use with extreme caution in patients with long-standing bronchial asthma and emphysema who have developed degenerative heart disease. Anginal pain may be induced when coronary insufficiency is present.
Use with caution in patients with pre-existing cardiac arrhythmias. Tissue necrosis at injection site may arise if this product is administered to an inappropriate injection site such as digits or buttocks.
Administer with caution: In patients suffering from autonomic dysreflexia (hyperreflexia), particularly in spinal cord injury (e.g., tetraplegics). Patients with hypersensitivity to sulfites and patients with prostatic hypertrophy or urination difficulty.
Endotracheal administration of adrenaline can contaminate the colorimeter carbon dioxide detector and lead to its false positive colour change (fixed yellow discoloration).
This medicinal product contains 2.7 mg per ml sodium. To be taken into consideration by patients on a controlled sodium diet.
This medicinal product contains sodium metabisulfite which may rarely cause severe hypersensitivity reactions and bronchospasm.
The effects of adrenaline may be potentiated by tricyclic antidepressants. Volatile liquid anaesthetics such as halothane increase the risk of adrenaline-induced ventricular arrhythmias and acute pulmonary oedema if hypoxia is present. Severe hypertension and bradycardia may occur with non-selective beta-blocking drugs such as propranolol. Propranolol also inhibits the bronchodilator effect of adrenaline. The risk of cardiac arrhythmias is higher when adrenaline is given to patients receiving digoxin or quinidine. Adrenaline -induced hyperglycaemia may lead to loss of blood-sugar control in diabetic patients treated with hypoglycaemic agents.
The vasoconstrictor and pressor effects of adrenaline, mediated by its alpha-adrenergic action, may be enhanced by concomitant administration of drugs with similar effects, such as ergot alkaloids or oxytocin. Adrenaline specifically reverses the antihypertensive effects of adrenergic neurone blockers such as guanethidine with the risk of severe hypertension.
Concurrent use or use within 2 weeks of monoamine oxidase inhibitor increases risk of adverse events. Sympathomimetic drugs (e.g. isoproterenol) increase the risk of serious cardiac arrhythmias. Alpha blockers increase the risk of hypotension and tachycardia. Drugs which cause potassium loss (corticosteroids, potassium-depleting diuretic, aminophylline, theophylline) increases the risk of hypokalemia. Adrenaline increases the risk of cardiac adverse effects of levodopa.
Use of Entacapone may potentiate the chronotropic and arrhythmogenic effects of adrenaline.
Adrenaline crosses the placenta. There is some evidence of a slightly increased incidence of congenital abnormalities. Injection of adrenaline may cause foetal tachycardia, cardiac irregularities, extrasystoles and louder heart sounds. In labour, adrenaline may delay the second stage. Adrenaline should only be used in pregnancy if the potential benefits outweigh the risks to the foetus.
Adrenaline is excreted in breast milk, but as pharmacologically active plasma concentrations are not achieved by the oral route, the use of adrenaline in breast feeding mothers is presumed to be safe.
Not applicable; this preparation is intended for use only in emergencies.
Nervous system disorders
Cerebral haemorrhage due to hypertension
The potentially severe adverse effects of adrenaline arise from its effect upon blood pressure and cardiac rhythm.
Pulmonary oedema due to hypertension
Renal and urinary disorders
Difficulty in micturition and urinary retention.
General disorders and administration site conditions
Biochemical effects include inhibition of insulin secretion, stimulation of growth hormone secretion, hyperglycaemia (even with low doses), involvement in the processes of gluconeogenesis, glycolysis, lipolysis and ketogenesis.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
Symptoms: cardiac arrhythmias leading to ventricular fibrillation and death; severe hypertension leading to pulmonary oedema and cerebral haemorrhage.
Treatment: combined alpha- and beta-adrenergic blocking agents such as labetalol may counteract the effects of adrenaline, or a beta-blocking agent may be used to treat any supraventricular arrhythmias and phentolamine to control the alpha-mediated effects on the peripheral circulation. Rapidly acting vasodilators such as nitrates and sodium nitroprusside may also be helpful.
Immediate resuscitation support must be available.
Adrenaline is a direct-acting sympathomimetic agent exerting its effect on alpha- and beta-adrenoceptors. The overall effect of adrenaline depends on the dose used, and may be complicated by the homeostatic reflex responses. In resuscitation procedures it is used to increase the efficacy of basic life support. It is a positive cardiac inotrope. Major effects are increased systolic blood pressure, reduced diastolic pressure (increased at higher doses), tachycardia, hyperglycaemia and hypokalaemia.
Adrenaline is rapid in onset and of short duration. After i.v. infusion the half-life is approximately 5-10 minutes. It is rapidly distributed to the heart, spleen, several glandular tissues and adrenergic nerves. It crosses the placenta and is excreted in breast milk. It is approximately 50% bound to plasma proteins.
Adrenaline is rapidly metabolised in the liver and tissues by oxidative deamination and O-methylation followed by reduction or by conjugation with glucuronic acid or sulfate. Up to 90% of the i.v. dose is excreted in the urine as metabolites.
Not applicable since Adrenaline (Epinephrine) Injection has been used in clinical practice for many years and its effects in man are well known.
Citric Acid Monohydrate
Sodium Citrate (E331)
Sodium Metabisulfite (E223)
Dilute Hydrochloric Acid (for pH adjustment)
Water for Injection
In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Adrenaline should not be mixed with sodium bicarbonate; the solution is oxidised to adrenochrome and then forms polymers.
3ml - 18 months.
10ml - 21 months.
Do not store above 25°C. Keep container in outer carton in order to protect from light.
The solution is contained in a 10 ml Type I glass syringe with a polycarbonate Luer lock connector, polystyrene plunger rod and latex-free bromobutyl rubber plunger stopper.
One syringe per carton.
The solution of the 3ml pack is contained in a Type I glass vial with a rubber elastomeric closure for use with a separate injector. (Not marketed).
Not all pack sizes maybe marketed.
For single use only. Discard any unused solution
Any unused product or waste material should be disposed of in accordance with local requirements.
International Medication Systems (UK) Ltd
21 St Thomas Street
21 March 1991 / 29 November 2005