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The eMC  

Last Updated 11 Apr 2007

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Trimovate cream

Trimovate (Trim-oh-vate) is a medicine which is used in inflammatory skin conditions where infection is also present. Trimovate contains clobetasone butyrate/nystatin/oxytetracycline calcium. It is made by GlaxoSmithKline UK.

The information in this Medicine Guide for Trimovate varies according to the condition being treated and the particular preparation used.

Trimovate cream

Information specific to Trimovate cream when used in inflammatory skin conditions where infection is also present

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Your medicine

Medicines are used to treat, control or prevent a condition. Some medicines will give you immediate relief from your symptoms while others take much longer to work.

Trimovate has been prescribed for your current medical problems and should not be used for other medical problems. Do not share your medicine with other people as it may not be suitable for them and could cause them harm. In the same way, you should not use medicines that belong to other people.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often to take your medicine. This is the dose that you and your prescriber have agreed you should take. Depending on your response to the medicine, how the medicine works and the goals of your treatment, your prescriber may vary your dose. You should not change the dose of your medicine unless you are told to do so by your prescriber.

Trimovate contains three different medicines - nystatin, oxytetracycline calcium and clobetasone butyrate. Trimovate is used to treat skin problems caused by inflammation where infection is present or there is a risk that infection may occur. Nystatin is an antifungal and oxytetracycline calcium is an antibacterial which together can help to treat certain types of skin infections. Clobetasone butyrate reduces inflammation and can help to relieve the symptoms of inflammatory skin problems. Trimovate may be used in the treatment of infected eczema, nappy rash and dermatitis.

Other information about Trimovate:

  • if your symptoms get worse or do not improve within seven days of starting treatment with Trimovate you should contact your prescriber
  • this medicine should only be used for a maximum of seven days in children

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by the times at which you take other medicines.

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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

In the case of Trimovate:

  • apply a thin layer to the affected area of skin
  • after Trimovate has been applied to the affected area of skin you should cover it with a dressing. This is to reduce the chance of Trimovate staining your clothes. Make sure that you know when and how to change the dressing. This is because a dressing that covers or seals the area can lead to moist or warm conditions. These conditions may make it more difficult to treat an infection. Changing the dressing regularly will help prevent this from happening
  • if you are applying this medicine to your face, you should not use it for long periods of time. For more information contact your prescriber
  • if you are using Trimovate on the eyelids take care not to get Trimovate into your eyes
  • do not dilute this medicine

If you are having problems taking this form of Trimovate, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. This is because the effects of taking too much medicine are very complex and it is therefore essential that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

If you are not having any problems with this medicine, do not stop taking it unless you have completed the course or you are advised to stop taking it by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

In the case of Trimovate:

  • do not store in temperatures above 25°C

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Trimovate is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for an infant or child.

Over time it is possible that Trimovate can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Trimovate has become unsuitable, it is important that the prescriber is contacted immediately.

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A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience. Very occasionally, certain side-effects can be beneficial.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

The frequency of these side-effects is unknown:

  • eye or eyesight problems if Trimovate gets into the eye
  • hair overgrowth
  • hiding symptoms of infection
  • hypersensitivity reactions such as redness, skin rashes, itching, burning sensation or dermatitis - if any type of hypersensitivity reaction happens you should stop applying Trimovate immediately and seek medical advice
  • if Trimovate is used in large amounts or for a long period of time, it may have some effects on the skin such as thinning or skin sensitivity reactions
  • if Trimovate is used in large amounts or for a long period of time, the amount of Trimovate which is absorbed into the body may be increased and certain side-effects may occur. These side-effects are related to the effect that steroids have on the whole body. These may include adrenal problems
  • increased absorption of Trimovate when the treated area of skin is covered with a nappy - this may make side-effects more likely to occur
  • skin colour changes
  • staining of hair, fabric or skin
  • worsening of the problem that Trimovate is being used to treat

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

There are no known important interactions between Trimovate and other medicines. If you experience any unusual symptoms while using Trimovate and other medicines you should tell your prescriber.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Trimovate.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicines Trimovate can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

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Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Trimovate:

  • there are no specific foods that you must exclude from your diet when using Trimovate
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Alcohol can interact with certain medicines.

In the case of Trimovate:

  • there are no known interactions between alcohol and Trimovate
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

Careful consideration needs to be given to the risks and the benefits of using this medicine during pregnancy.

You need to discuss your specific circumstances with your doctor to make a decision about whether you are going to take this medicine during pregnancy. You should only take this medicine during pregnancy if your doctor thinks you need to take it. If the decision is that you should not have Trimovate, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

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Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

You should check that you are able to take the ingredients in your medicine, especially if you have any allergies.

Trimovate contains:

  • cetostearyl alcohol
  • chlorocresol
  • clobetasone butyrate, nystatin and oxytetracycline calcium
  • dimethicone 20
  • disodium hydrogen phosphate anhydrous
  • glycerol
  • glyceryl monostearate
  • polyoxyl 40 stearate
  • purified water
  • sodium acid phosphate
  • sodium metabisulphite
  • titanium dioxide
  • white soft paraffin

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Trimovate before, do not take Trimovate. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Trimovate, Version 2, last updated 11 Apr 2007