This site uses cookies. By continuing to browse the site you are agreeing to our policy on the use of cookies. Find out more here.

Continue >
The eMC  

Last Updated 15 Jul 2015

You are viewing:

Prochlorperazine 5mg tablets

Prochlorperazine maleate (Proh-clor-pair-raz-een mal-ee-ate) is a medicine which is used in a number of conditions.

The information in this Medicine Guide for Prochlorperazine maleate varies according to the condition being treated and the particular preparation used.

There are 2 preparations of Prochlorperazine maleate available. If Prochlorperazine 5mg tablets is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Prochlorperazine maleate

Prochlorperazine 5mg tablets

Information specific to Prochlorperazine 5mg tablets when used in nausea and vomiting

Print this medicine guide

Can't read the PDF? Download Adobe Reader at

Your medicine

Prochlorperazine maleate is used to treat a variety of mental health problems. It works by blocking the effect of a chemical in the brain which is thought to affect thinking, feelings and behaviour. It can help to treat the symptoms of schizophrenia or mania. Prochlorperazine maleate may be used with other medicines to treat anxiety.

Prochlorperazine maleate can also be used to treat nausea, vomiting or vertigo.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Back to top

When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines. Make sure you follow any specific instructions given to you by your prescriber or that are in the Patient Information Leaflet that comes with this medicine.

Back to top

How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

Specific information on how to take Prochlorperazine maleate can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to take your medicine from your doctor or pharmacist.

If you are having problems taking this form of Prochlorperazine maleate, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

Back to top

Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

Back to top

Stopping your medicine

If you are not having any problems taking this medicine then do not stop taking it, even if you feel better, unless advised to do so by your prescriber. If, however, you find that this medicine is causing you problems then you should talk to your prescriber about your concerns.

If your medical team decides that it is best that you do not take this medicine any more, they may advise that you do not stop Prochlorperazine maleate abruptly. This is because, in some instances, stopping Prochlorperazine maleate abruptly can cause withdrawal symptoms or cause your original condition to return. In these instances, reducing the dose of Prochlorperazine maleate gradually over time may reduce the chances of having these problems.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

Back to top

Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

Specific information on how to look after Prochlorperazine maleate can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to look after your medicine from your doctor or pharmacist.

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

Back to top

Whether this medicine is suitable for you

Prochlorperazine maleate is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child who is under one year of age or who weighs less than 10 Kg.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care
  • to check that this medicine is not having any undesired effects

Over time it is possible that Prochlorperazine maleate can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Prochlorperazine maleate has become unsuitable, it is important that the prescriber is contacted immediately.

Back to top


A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

The frequency of these side-effects is unknown:

  • a drop in blood pressure on standing or sitting up
  • abnormal muscle movements or problems controlling muscle movement
  • blocked nose
  • blood and bone marrow problems - seek immediate medical advice if you get any signs of an infection
  • convulsions
  • death
  • difficulty sleeping
  • dry mouth
  • ECG changes
  • eye or eyesight problems
  • faster heart rate
  • feeling agitated
  • feeling drowsy
  • feeling restless and inability to sit still
  • fever - seek immediate medical advice if you get a fever
  • glucose intolerance
  • heart problems which may lead to cardiac arrest - some heart problems may be fatal
  • hypersensitivity reactions such as angioedema or urticaria
  • impaired body-temperature control
  • impotence
  • increased blood sugar levels
  • jaundice - seek medical advice if you develop jaundice
  • lowered blood pressure
  • metabolic problems - these problems may lead to galactorrhoea, amenorrhoea, or breast enlargement in men
  • neuroleptic malignant syndrome - seek immediate medical advice if you are pale or sweating or if you have stiff muscles, autonomic dysfunction or changes in consciousness
  • oculogyric crisis
  • photosensitivity skin reaction - this may happen after exposing skin to sunlight. You should try to protect your skin from sunlight while you are having Prochlorperazine maleate
  • respiratory depression
  • skin colour changes - these have happened in people taking medicines similar to Prochlorperazine maleate
  • skin rash or rashes
  • skin reactions - this may occur if Prochlorperazine maleate is handled frequently
  • tardive dyskinesia - this may also occur after treatment with Prochlorperazine maleate has stopped
  • thromboembolism such as deep vein thrombosis or pulmonary embolism
  • withdrawal symptoms can occur when this medicine is stopped abruptly. These include nausea, vomiting, difficulty sleeping or extrapyramidal side-effects

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

Back to top

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Prochlorperazine maleate:

The following types of medicine may interact with Prochlorperazine maleate:

If you are taking Prochlorperazine maleate and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Back to top

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Prochlorperazine maleate.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

Back to top

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Prochlorperazine maleate:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

Back to top


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Prochlorperazine maleate:

  • there are no specific foods that you must exclude from your diet when taking Prochlorperazine maleate
Back to top


Alcohol can interact with certain medicines.

In the case of Prochlorperazine maleate:

  • alcohol may increase the effects of this medicine

You should seek advice from your prescriber as to whether you may drink alcohol while taking this medicine.

Back to top

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Prochlorperazine maleate:

  • the use of this medicine during pregnancy is not recommended. You should only take this medicine during pregnancy if your doctor thinks that you need it
  • if you take this medicine during the late stages of pregnancy, your baby may have some withdrawal symptoms from Prochlorperazine maleate after it is born. Your baby may also need to have some extra monitoring after birth

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Prochlorperazine maleate, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

Back to top


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Prochlorperazine maleate:

  • women who are taking Prochlorperazine maleate should not breast-feed

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

Back to top

Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

This medicine contains prochlorperazine maleate.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies. You should also check whether any of these ingredients are known to have side-effects.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Prochlorperazine maleate before, do not take Prochlorperazine maleate. Talk to your prescriber, pharmacist or nurse as soon as possible.

Back to top

Prochlorperazine maleate, Version 13, last updated 15 Jul 2015