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The eMC  

Last Updated 07 Mar 2014

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Perfalgan 1g/100ml solution for infusion vials

Perfalgan (purf-al-gan) is a medicine which is used in pain relief and reduction of fever. Perfalgan contains paracetamol. It is supplied by Bristol-Myers Squibb Pharmaceuticals Ltd.

The information in this Medicine Guide for Perfalgan varies according to the condition being treated and the particular preparation used.

There are 2 preparations of Perfalgan available. If Perfalgan 1g/100ml solution for infusion vials is not the preparation you are looking for, please select from the drop down list below.

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Perfalgan 1g/100ml solution for infusion vials

Information specific to Perfalgan 1g/100ml solution for infusion vials when used in pain relief

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Your medicine

Perfalgan is an injectable form of the medicine paracetamol, which helps to relieve pain and reduce fever. It is used when an injectable form of the medicine is needed because a tablet or liquid cannot be used.

Other information about Perfalgan:

  • your prescriber will make sure that you change from injection to oral treatment as soon as possible

Perfalgan is usually given to you by a healthcare professional. The person responsible for giving you your medicine will make sure that you get the right dose.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber or someone involved in your medical care.

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When to take your medicine

The person with responsibility for giving you your medicine will make sure that you have your medicine at the prescribed times.

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How to take your medicine

This medicine will be given to you as an injection. If you have any concerns about this medicine or how this will be given to you, talk to someone who is involved in your medical care.

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Taking too much of your medicine

Having extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems.

In the case of Perfalgan, the person who is responsible for giving you your medicine will make sure that you are given the correct dose.

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Stopping your medicine

The person in charge of your care will make the decision about when you should stop this medicine. If you experience any problems while having this medicine, talk to someone who is involved in your medical care.

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Looking after your medicine

As Perfalgan will be given to you as an injection, it will usually be stored by the medical team.

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Whether this medicine is suitable for you

Perfalgan is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who weighs less than 33 kg.

Over time it is possible that Perfalgan can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Perfalgan has become unsuitable, it is important that the prescriber is contacted immediately.

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A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Rare: More than 1 in 10,000 people who have Perfalgan:

Very rare: Fewer than 1 in 10,000 people who have Perfalgan:

  • blood problems
  • hypersensitivity reactions - seek medical advice if you develop skin rash or rashes, urticaria or an anaphylactic reaction

The frequency of these side-effects is unknown:

  • faster heart rate
  • flushing
  • injection site problems such as pain or burning sensation
  • itching
  • redness of the skin

If you feel unwell or if you have concerns about a side-effect, tell the person looking after you immediately.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Perfalgan:

  • probenecid
  • propacetamol
  • salicylamide

The following types of medicine may interact with Perfalgan:

If you are taking Perfalgan and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are, or have recently been, taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Perfalgan.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicines Perfalgan can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

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Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Perfalgan:

  • there are no specific foods that you must exclude from your diet when having Perfalgan
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Alcohol can interact with certain medicines.

In the case of Perfalgan:

  • there are no known interactions between alcohol and Perfalgan
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Perfalgan:

  • you should only have this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Perfalgan, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

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Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Perfalgan:

  • this medicine may be used by women who are breast-feeding

If you are having Perfalgan and plan to breast-feed you must inform your doctor or midwife.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. Some may be used to prolong the life of the medicine.

Perfalgan contains:

  • cysteine hydrochloride monohydrate
  • disodium phosphate dihydrate
  • hydrochloric acid
  • mannitol
  • sodium hydroxide
  • water for injections

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Perfalgan before, do not have Perfalgan. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Perfalgan, Version 8, last updated 07 Mar 2014