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The eMC  

Last Updated 25 Sep 2014

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Moxifloxacin 400mg tablets

Moxifloxacin hydrochloride (Mox-ee-flox-ass-in hi-droh-clor-ride) is a medicine which is used in certain types of bacterial infections and eye infections.

The information in this Medicine Guide for Moxifloxacin hydrochloride varies according to the condition being treated and the particular preparation used.

There are 3 preparations of Moxifloxacin hydrochloride available. If Moxifloxacin 400mg tablets is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Moxifloxacin hydrochloride

Moxifloxacin 400mg tablets

Information specific to Moxifloxacin 400mg tablets when used in certain types of bacterial infections

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Your medicine

Moxifloxacin hydrochloride is used to treat certain types of bacterial infections. It works by killing certain types of bacteria.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most benefit from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines.

Specific information on when to take Moxifloxacin hydrochloride can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. You can also ask your doctor or pharmacist for information about when to take your medicine.

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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

Specific information on how to take Moxifloxacin hydrochloride can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to take your medicine from your doctor or pharmacist.

If you are having problems taking this form of Moxifloxacin hydrochloride, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

If you are not having any problems with this medicine, do not stop taking it, even if you feel better, unless you have completed the course or you are advised to stop taking it by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

Specific information on how to look after Moxifloxacin hydrochloride can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to look after your medicine from your doctor or pharmacist.

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Moxifloxacin hydrochloride is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under 18 years of age.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care
  • to check that this medicine is not having any undesired effects

Over time it is possible that Moxifloxacin hydrochloride can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Moxifloxacin hydrochloride has become unsuitable, it is important that the prescriber is contacted immediately.

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Side-effects

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Common: More than 1 in 100 people who take Moxifloxacin hydrochloride:

  • abnormal laboratory test results
  • antibiotic resistance to Moxifloxacin hydrochloride - this may lead to other types of infection
  • diarrhoea - seek immediate medical advice if you get diarrhoea
  • ECG changes
  • feeling dizzy
  • gastrointestinal pain
  • headaches
  • heart rhythm changes in people with metabolic problems
  • nausea
  • vomiting

Uncommon: More than 1 in 1000 people who take Moxifloxacin hydrochloride:

  • allergic or hypersensitivity reactions - you or your carer should seek immediate medical advice if you get an allergic or a hypersensitive reaction
  • angina
  • blood and bone marrow problems
  • breathing difficulties including asthma
  • changes in blood clotting time
  • confusion
  • constipation
  • decreased appetite
  • dehydration
  • difficulty sleeping
  • dry skin
  • eye or eyesight problems - seek immediate medical advice if you get double vision, blurred vision, loss of vision or any other eyesight problem
  • faster heart rate
  • feeling anxious
  • feelings of disorientation
  • flatulence
  • gastritis
  • heart problems
  • high levels of lipids in the blood
  • indigestion
  • itching
  • liver problems which may be fatal - seek immediate medical advice if you develop symptoms such as a tendency to bleed, jaundice, weakness or dark urine
  • pain including back pain, chest pain, pelvic pain, muscle pain, joint pain or pain in the extremities
  • palpitations
  • paraesthesiae
  • psychomotor agitation
  • skin rash or rashes - seek immediate medical advice if you develop a rash or any type of skin reaction
  • sleepiness
  • sleeping problems
  • sweating
  • taste changes
  • tiredness
  • tremors
  • urticaria
  • vasodilatation
  • vertigo
  • weakness

Rare: More than 1 in 10,000 people who take Moxifloxacin hydrochloride:

  • anaphylactic reactions such as angioedema, laryngeal oedema or shock - seek immediate medical advice if you get these reactions
  • blood pressure changes
  • changes in emotions
  • changes to sense of smell including loss of sense of smell
  • concentration problems
  • coordination problems including abnormal gait
  • depression - this may lead to self-endangering behaviour such as having thoughts of committing suicide or suicide attempts. You or your carer must seek immediate medical advice if you: are depressed; have thoughts of committing suicide; or if you have attempted suicide
  • fainting or brief loss of consciousness
  • hallucinations
  • hearing problems including deafness
  • high blood sugar
  • hypoaesthesia
  • inflammation of the mouth
  • jaundice
  • kidney problems
  • memory problems
  • metabolic problems
  • muscle cramps
  • muscle twitching
  • muscle weakness
  • neuropathies such as neuropathy of the extremities - seek medical advice if symptoms occur such as pain, burning sensation, tingling, numbness or weakness
  • oedema
  • pseudomembranous colitis - this may be fatal. Seek immediate medical advice if you get symptoms such as diarrhoea or colitis
  • seizures - stop taking Moxifloxacin hydrochloride and seek immediate medical advice if you have seizures
  • speech problems
  • strange dreams
  • swallowing difficulties
  • tendon problems including tendon inflammation and rupture - these problems may be delayed and may occur several months after you have stopped taking Moxifloxacin hydrochloride. Seek immediate medical advice if you get pain or inflammation in your tendons
  • tinnitus

Very rare: Fewer than 1 in 10,000 people who take Moxifloxacin hydrochloride:

  • arthritis
  • cardiac arrest
  • depersonalisation
  • hypersensitivity to external stimuli such as light, noise and physical contact
  • muscle stiffness or wasting
  • psychosis or psychotic-like behaviour - this may lead to self-endangering behaviour such as having thoughts of committing suicide or suicide attempts. You or your carer must seek immediate medical advice if you: are depressed; have thoughts of committing suicide; or if you have attempted suicide
  • skin problems such as Stevens-Johnson syndrome or toxic epidermal necrolysis - seek immediate medical advice if you develop any type of skin or mucous membranes reactions while taking Moxifloxacin hydrochloride
  • worsening of myasthenia gravis

The frequency of these side-effects is unknown:

  • may affect the results for certain tests
  • photosensitivity skin reaction - you should avoid exposure to ultraviolet radiation or strong sunlight while you are taking Moxifloxacin hydrochloride
  • rhabdomyolysis

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Moxifloxacin hydrochloride:

The following types of medicine may interact with Moxifloxacin hydrochloride:

If you are taking Moxifloxacin hydrochloride and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Moxifloxacin hydrochloride:

If you have been prescribed Moxifloxacin hydrochloride you should only take something on the above list on the specific advice of your prescriber or pharmacist.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Moxifloxacin hydrochloride:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

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Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Moxifloxacin hydrochloride:

  • there are no specific foods that you must exclude from your diet when taking Moxifloxacin hydrochloride
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Alcohol

Alcohol can interact with certain medicines.

In the case of Moxifloxacin hydrochloride:

  • there are no known interactions between alcohol and Moxifloxacin hydrochloride
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Moxifloxacin hydrochloride:

  • do not take this medicine during pregnancy

This medicine is not suitable during pregnancy. It is very important that you seek urgent medical advice if you become pregnant or think you have become pregnant while taking this medicine.

If you are planning to become pregnant, you should discuss your personal circumstances with your doctor so that together you can make a decision about what treatment you may need during your pregnancy.

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Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Moxifloxacin hydrochloride:

  • women who are taking Moxifloxacin hydrochloride should not breast-feed
  • this medicine passes into breast milk

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

This medicine contains moxifloxacin hydrochloride.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies. You should also check whether any of these ingredients are known to have side-effects.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Moxifloxacin hydrochloride before, do not take Moxifloxacin hydrochloride. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Moxifloxacin hydrochloride, Version 18, last updated 25 Sep 2014