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The eMC  

Last Updated 09 Jul 2015

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Dermovate 0.05% cream

Dermovate (Der-moh-vate) is a medicine which is used in inflammatory skin conditions. Dermovate contains clobetasol propionate. It is supplied by GlaxoSmithKline UK.

The information in this Medicine Guide for Dermovate varies according to the condition being treated and the particular preparation used.

There are 3 preparations of Dermovate available. If Dermovate 0.05% cream is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Dermovate

Dermovate 0.05% cream

Information specific to Dermovate 0.05% cream when used in Inflammatory skin conditions

Your medicine

Dermovate reduces inflammation and can help to relieve the symptoms of inflammatory skin problems. Dermovate is only used when the skin problem has not responded well to previous treatment with a less active steroid.

Other information about Dermovate:

  • if you are an adult and applying this medicine to your face, you should not use it for more than five days
  • this medicine can only be used for a maximum of five days in children
  • your prescriber will review the need for you to continue treatment with Dermovate on a regular basis
  • your prescriber will try to find the lowest dose of your medicine for the shortest time to control your condition
  • if your symptoms get worse or do not improve within two to four weeks of starting treatment with Dermovate you should contact your prescriber
  • this medicine should not be used for longer than five days if the treatment area is tightly covered or sealed with a dressing

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should use. It also tells you how often you should use your medicine. This is the dose that you and your prescriber have agreed you should use. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by the times at which you take other medicines.

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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

In the case of Dermovate:

  • apply a thin layer to the affected area of skin
  • if you are applying Dermovate to the face or to a child, do not tightly cover or seal the treated area of skin with bandages or plasters
  • if you are using a dressing that covers or seals the area being treated, make sure that you know when and how to change the dressing. This is because a dressing that covers or seals the area can lead to moist or warm conditions which may increase the chance of getting infections
  • if you are using Dermovate on the eyelids take care not to get Dermovate into your eyes. If you do get any of the medicine into your eyes, bathe the affected eye with plenty of water
  • after applying your medicine, wash your hands. Do not wash your hands if the medicine is meant for use on your hands

If you are having problems taking this form of Dermovate, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

If you are not having any problems taking this medicine then do not stop using it, even if you feel better, unless advised to do so by your prescriber. If, however, you find that this medicine is causing you problems then you should talk to your prescriber about your concerns.

If your medical team decides that it is best that you do not take this medicine any more, they may advise that you do not stop Dermovate abruptly. This is because, in some instances, stopping Dermovate abruptly can cause withdrawal symptoms or cause your original condition to return. In these instances, reducing the dose of Dermovate gradually over time may reduce the chances of having these problems.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. You should keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

In the case of Dermovate:

  • do not store in temperatures above 25°C

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Dermovate is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a bad reaction to corticosteroids in the past
  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • have a large area of skin that needs treating with Dermovate
  • have inflamed skin which needs treatment in the area around the mouth, back passage, the genitals or other areas where the skin is thin
  • have kidney problems
  • have liver problems
  • have skin problems such as rosacea, acne, nappy rash or an untreated infection in the area where Dermovate needs to be applied

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under the age of 12 years.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is not having any undesired effects

Over time it is possible that Dermovate can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Dermovate has become unsuitable, it is important that the prescriber is contacted immediately.

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A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Common: More than 1 in 100 people who use Dermovate

Uncommon: More than 1 in 1000 people who use Dermovate

  • if Dermovate is used in large amounts or for a long period of time, the amount of Dermovate which is absorbed into the body may be increased and certain side-effects may occur. These side-effects are related to the effect that corticosteroids have on the whole body. These may include Cushing's syndrome or cushing-like symptoms like moon face, central obesity or adrenal problems. Some of these adrenal problems may lead to skin problems such as dryness, wrinkling, skin colour changes, thinning of the skin, striae or telangiectasia

Very rare: Fewer than 1 in 10,000 people who use Dermovate

The frequency of these side-effects is unknown

  • allergic reactions
  • Dermovate tolerance
  • increased absorption of Dermovate when the treated area of skin is in a skin fold or if the area is tightly covered or sealed - this may make side-effects more likely to occur

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Dermovate:

The following types of medicine may interact with Dermovate:

If you are taking Dermovate and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Dermovate.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicines Dermovate can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

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Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Dermovate:

  • there are no specific foods that you must exclude from your diet when using Dermovate
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Alcohol can interact with certain medicines.

In the case of Dermovate:

  • there are no known interactions between alcohol and Dermovate
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Dermovate:

  • you should only use this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Dermovate, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

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Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Dermovate:

  • it is not known whether this medicine passes into breast milk

Before you use Dermovate you should discuss breast-feeding with your doctor or midwife. Your doctor will weigh up the overall risks and benefits of you using this medicine and decide what is best for you and your baby. You should only breast-feed your baby while using this medicine on the advice of your doctor. If the decision is that you could use Dermovate, you should not apply it on the breast.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

You should check that you are able to take the ingredients in your medicine, especially if you have any allergies.

Dermovate contains:

  • arlacel 165
  • beeswax substitute 6621
  • cetostearyl alcohol
  • chlorocresol
  • citric acid monohydrate
  • glyceryl monostearate
  • propylene glycol
  • purified water

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Dermovate before, do not use Dermovate. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Dermovate, Version 7, last updated 09 Jul 2015