EFFICO TONIC

Each 5ml oral liquid contains:

Clear colourless to pale straw coloured slightly viscous liquid

A gentle pick-me-up and appetite promoter to combat the depressing effects that occur when tired, listless, run down, after a weakening illness or hospitalisation and due to too little nicotinamide and B₁.

Adults and elderly:

10ml immediately before meals, three times a day.

Children (over 6 years):

2.5 to 5 ml taken as for adults.

Method of administration - oral use

Use in patients with known hypersensitivity to the product.

None stated

None stated

Contra-indicated in pregnancy and lactation unless considered essential by the physician.

None stated

None stated

None stated

Caffeine is a mild CNS stimulant and its inclusion in the formulation helps counteract symptoms of tiredness and listlessness after a weakening illness or hospitalisation.

Thiamine and nicotinamide are present as vitamin supplements. Deficiencies of these two vitamins produce symptoms including fatigue and lethargy with anorexia or loss of appetite.

Nicotinamide is readily absorbed from the gastrointestinal tract. It has a short half-life and after low doses, the principle metabolites are the N-methyl, 2- and 4- pyridone derivatives.

Thiamine is absorbed from the gastrointestinal tract and widely distributed to most body tissues. It is not stored in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites.

Caffeine is absorbed readily after oral administration. The average half-life is reported to be 3.5 hours. Peak plasma concentrations of 1.5 to 1.8 mg/litre have been measured after a 100mg oral dose.

There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.

Ethanol 96%

Sodium Benzoate

Citric acid

Concentrated Hydrochloric Acid

Sucrose

Compound Gentian Infusion

H & R Summer Fruit flavour 288234

Purified Water

None stated

Clear colourless or amber glass – 3 years

Clear colourless polyethene terephthalate (PET) or orange coloured PET – 2 years

Store away from direct sunlight below 25°C

Clear colourless or amber glass bottle, or clear colourless polyethene terephthalate (PET) or orange coloured PET bottle with food-grade polypropylene tamper-evident cap pigmented with titanium dioxide containing 300ml or 500ml.

None stated

PL 0108/5013

24th November 1988 / 24 November 2003

March 2010

GSL