| Condition | | Adults Dosage (including elderly) | Children's Dosage ( < 40 kg) | Notes |
| Dental Procedures: Prophylaxis for patients undergoing extraction, scaling or surgery involving gingival tissues, and who have not received a penicillin in the previous month.
(N.B. Patients with prosthetic heart valves should be referred to hospital – see below.)
| Patients not having general anaesthetic.
| 3 g Amoxicillin orally, 1 hour before procedure. A second dose may be given 6 hours later, if considered necessary.
| 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure
| Note 1.
If prophylaxis with Amoxicillin is given twice within one month, emergence of resistant streptococci is unlikely to be a problem. Alternative antibiotic are recommended if more frequent prophylaxis, or if the patient has received a course of treatment with a penicillin during the previous month.
Note 2.
To minimise pain on injection, Amoxicillin may be given as two injections of 500 mg dissolved in sterile 1% lignocaine solution. (see Administration).
|
| | Patient having general anaesthetic: if oral antibiotics considered to be appropriate.
| Initially 3 g Amoxicillin orally 4 hours prior to anaesthesia, followed by 3 g orally (or 1 g IV or IM if oral dose not tolerated) as soon as possible after the operation.
| | |
| | Patient having general anaesthetic: if oral antibiotic not appropriate.
| 1 g Amoxicillin IV or IM immediately before induction; with 500 mg orally, 6 hours later.
| | |
| Dental Procedures: Patients for whom referral to hospital is recommended:
(a) patients to be given a general anaesthetic who have been given a penicillin in the previous month.
(b) patients to be given a general anaesthetic who have a prosthetic heart valve.
(c) patients who have had one or more attacks of endocarditis.
| Initially: 1 g Amoxicillin IV or IM with 120 mg gentamicin IV or IM, immediately prior to anaesthesia (if given) or 15 minutes prior to dental procedure.
Followed by (6 hours later): 500 mg Amoxicillin orally
| 50 mg
amoxicillin/kg body
weight given as a
single dose one
hour preceding the
surgical procedure
| See note 2.
Note 3. Amoxicillin and gentamicin should not be mixed in the same syringe.
Note 4. Please consult the appropriate data sheet for full prescribing information on gentamicin.
|
| Genito-urinary Surgery or Instrumentation: Prophylaxis for patients who have no urinary tract infection and who are to have genitourinary surgery or instrumentation under general anaesthesia.
In the case of Obstetric and Gynaecological Procedures and Gastro-intestinal Procedures – Routine prophylaxis is recommended only for patients with prosthetic heart valves.
| Initially: 1 g Amoxicillin IV or IM with 120 mg gentamicin IV or IM, immediately before induction.
Followed by (6 hours later): 500 mg Amoxicillin orally or IV or IM according to clinical condition.
| | See Notes 2, 3, and 4 above.
|
| Surgery or Instrumentation of the Upper Respiratory Tract
| Patients other than those with prosthetic heart valves.
| 1 g Amoxicillin IV or IM immediately before induction; 500 mg Amoxicillin IV or IM 6 hours later.
| 50 mg
amoxicillin/kg body
weight given as a
single dose one
hour preceding the
surgical procedure
| See Note 2 above. Note 5. The second dose of Amoxicillin may be administered orally as Amoxicillin Syrup.
|
| Patients with prosthetic heart valves
| Initially: 1 g Amoxicillin IV or IM with 120 mg gentamicin IV or IM, immediately before induction; followed by (6 hours later) 500 mg Amoxicillin IV or IM.
| 50 mg
amoxicillin/kg body
weight given as a
single dose one
hour preceding the
surgical procedure
| See Notes 2, 3, 4 and 5 above.
|
