J Collis Browne's Tablets

Uncoated tablet

For the symptomatic relief of occasional diarrhoea.

Oral.

Adults and the Elderly:

Two or three tablets at once, then two or three tablets every four hours.

Children aged 6 to 10 years

One tablet at once, then one tablet every four hours.

Children under 6 years

Not recommended

Contraindicated in acute respiratory depression (asthma), acute alcoholism, paralytic ileus, acute ulcerative colitis, raised intra-cranial pressure and head injury. Hypersensitivity to any of the ingredients.

If symptoms persist for more than 48 hours, consult the doctor.

Keep out of the reach of children. Do not exceed the stated dose.

Do not take more than 6 doses in 24 hours. In addition to taking these tablets, it is important to replace body fluids lost during diarrhoea.

Not recommended for children under 6 years of age.

This product should be given with caution to patients exhibiting the following clinical conditions: hypotension, hypothyroidism, prostatic hypertrophy, renal or hepatic impairment, convulsive disorders, dependence, also if elderly or debilitated.

The depressant effects of opioid analgesics are enhanced by other CNS depressants such as alcohol, anxiolytics, hypnotics, antidepressants including tricyclic antidepressants, anticoagulants such as warfarin, antiepileptics and antipsychotics.

Morphine may interact with monoamine oxidase inhibitors (MAOI's) or within 14 days of stopping such treatment. If opioid analgesics are required they should be given with extreme caution. The effects of morphine in reducing gastrointestinal motility may interfere with the absorption of antiarrhythmics such as mexiletine, and may counteract the stimulatory effect of metoclopramide, domperidone and cisapride.

Cimetidine inhibits the metabolism of some opioids.

No known effects in pregnancy and lactation. However, as with all medicines, use with caution.

No known effects.

Side effects are nausea, vomiting, constipation, drowsiness, difficulty in micturition, ureteric or biliary spasm, dry mouth, sweating, headache, facial flushing, vertigo, bradycardia, tachycardia, palpitations, postural hypotension, hypothermia, hallucinations, dysphoria, mood changes, dependence, miosis, decreased libido or potency, rashes, urticaria and pruritus.

Gastric lavage and symptomatic treatment as for morphine hydrochloride is recommended.

Naloxone may be used to counteract central nervous system depression.

Light kaolin is absorbent and, when given by mouth, absorbs toxic and other substances from the alimentary tract.

Morphine, among other actions, diminishes propulsive peristalsis in the intestinal tract.

It is an effective agent for treating diarrhoea.

Calcium carbonate is an antacid that also has a constipating effect.

No pharmacokinetic studies have been carried out.

None stated.

Magnesium stearate, sodium polymetaphosphate, sucrose (icing sugar), talc, dispersed pink 11150 (contains E127), liquorice powder 07123937, peppermint flavour extra

None stated.

Three years unopened.

None

250 micron rigid uPVC 25µ aluminium foil blisters in cardboard cartons in packs of 18 or 36 tablets

None stated.

Thornton & Ross Limited

Linthwaite

Huddersfield

West Yorkshire

HD7 5QH

United Kingdom

PL 00240/0092

15 January 2003

Not Applicable

Not Applicable