J Collis Browne's Mixture.

Each 5ml contains:

Morphine hydrochloride equivalent to 1.0mg anhydrous Morphine Peppermint Oil 1.5 microlitre

Aqueous based mixture.

For the alleviation of coughs and the symptoms of diarrhoea.

Oral

Adults, the Elderly and Children over 12 years of age

For coughs: One to two 5 ml medicinal teaspoonsful. May be repeated every four hours.

For diarrhoea: Two to three 5 ml medicinal teaspoonsful. May be repeated once or twice at four hourly intervals if required.

Children aged 6 to 12 years of age

For coughs: One 5 ml medicinal teaspoonful. May be repeated every four hours.

For diarrhoea: One 5 ml medicinal teaspoonful. May be repeated once or twice at four hourly intervals if required

Not suitable for children under 6 years of age

Contraindicated in acute respiratory depression (asthma), acute alcoholism, paralytic ileus, acute ulcerative colitis, raised intra-cranial pressure and head injury.

Hypersensitivity to any of the ingredients.

Do not exceed the stated dose.

If symptoms persist, consult the doctor.

Keep out of the reach of children.

This product should be given with caution to patients exhibiting the following clinical conditions: hypotension, hypothyroidism, prostatic hypertrophy, renal or hepatic impairment, convulsive disorders, dependence, also if elderly or debilitated

The depressant effects of opioid analgesics are enhanced by other CNS depressants such as alcohol, anxiolytics, hypnotics, antidepressants including tricyclic antidepressants, anticoagulants such as warfarin, antiepileptics and antipsychotics.

Anhydrous morphine may interact with monoamine oxidase inhibitors (MAOI's) or within 14 days of stopping such treatment. If opioid analgesics are required they should be given with extreme caution. The effects of anhydrous morphine in reducing gastrointestinal motility may interfere with the absorption of antiarrhythmics such as mexiletine, and may counteract the stimulatory effect of metoclopramide, domperidone and cisapride.

Cimetidine inhibits the metabolism of some opioids.

No known effects in pregnancy and lactation. However, as with all medicines, use with caution.

No known effects.

Side effects are nausea, vomiting, constipation, drowsiness, difficulty in micturition, ureteric or biliary spasm, dry mouth, sweating, headache, facial flushing, vertigo, bradycardia, tachycardia, palpitations, postural hypotension, hypothermia, hallucinations, dysphoria, mood changes, dependence, miosis, decreased libido or potency, rashes, urticaria and pruritus.

Gastric lavage and symptomatic treatment as for morphine is recommended. Naloxone may be used to counteract central nervous system depression.

Morphine, among other actions, diminishes propulsive peristalsis in the intestinal tract. It is an effective agent for treating diarrhoea. Peppermint Oil is a carminative which relieves flatulence and intestinal griping.

No information available.

None stated.

None stated.

Five years unopened.

No special precautions for storage.

Amber glass bottle with 28mm white polypropylene cap with tamper evident band and EPE/Aluminium/Melinex/ liner in packs of 45ml and 100ml quantities.

No special requirements.

Thornton &Ross Limited

Linthwaite

Huddersfield

West Yorkshire

HD7 5QH

United Kingdom

PL 00240/0088

25 November 2002

20/01/2009