Allens Pine and Honey Balsam

Covonia Herbal Mucus Cough Syrup

Ipecacuanha liquid extract 0.0076ml/5ml

Liquorice liquid extract 0.l25m1/5ml

Squill oxymel 0.78ml/5ml

For full list of excipients, see section 6.1

Syrup

A traditional herbal remedy used for relief of the symptoms of coughs, colds and bronchitis.

Oral

Recommended doses and dosage schedule

Adults and children over 12 years: l0ml

Elderly: dose as for adults, unless otherwise directed.

The dose may be repeated after 4 hours if required.

Squill should not be administered to patients with impaired renal function, and is inadvisable in patients with cardiac disorders. Sensitivity to colophony containing products e.g. some lipsticks and eyeshadows etc.

Children under 12 years of age

Shake the bottle.

Keep all medicines away from children.

Do not give to children under 12 years.

Administration with carbenoxolone or diuretics may cause increased toxicity of squill if hypokalaemia occurs.

All drugs should be avoided if possible during the first trimester. Insufficient evidence is available to indicate safety of this product during pregnancy or lactation.

No effects known.

Adverse effects of squill include nausea and vomiting, which may also be caused by ipecacuanha which has an irritant effect on the gastrointestinal tract. Emetine is known to accumulate in muscle and may interfere with muscle fibre contactility of heart muscle.

Liquorice may cause reversible sodium retention and potassium loss leading to hypertension, water retention and electrolyte imbalance.

The symptoms of overdose of squill and ipecacuanha include nausea and vomiting. Treatment of overdose would depend upon the symptoms, cardiac irregularities, which may be caused by squill, may be treated by emesis or aspiration and lavage. In cases of severe cardiac arrhythmias, potassium and/or anti-arrhythmic agents may be given. Prolonged vomiting may be a symptom of overdose of ipecacuanha alkaloids, which may be controlled by intramuscular injection of 25 -50mg of chlorpromazine or of a comparable dose of a related phenothiazine; fluid and electrolyte imbalance should also be corrected.

Squill is used for its reflex expectorant action. Liquorice acts as a demulcent and expectorant. Ipecacuanha, in small doses, has a reflex expectorant action useful for the treatment of the symptoms of acute and chronic bronchitis, and in coughs

Several procedures have been reported for the determination of ipecacuanha alkaloids but the classical acid-based titrimetric method would still appear to be the recommended one.

None

Pumilio Pine Oil

Anise oil

Capsicum tincture

Chloroform

Ethanol (96%)

Diethyl ether (peroxide free)

Arrowroot

Menthol

Peppermint oil

Syrup

Treacle black

Purified water

None known

150m1: 36 months unopened.

Store below 25°C.

150ml bottle-amber glass with a child resistant tamper evident 28mm cap with a Melinex/Aluminium/EPE liner.

150ml Amber glass bottle embossed "Covonia" with a child resistant tamper evident 28mm cap with Melinex/Aluminium/EPE liner.

None

Thornton & Ross Ltd.,

Linthwaite Laboratories,

Huddersfield,

HD7 5QH

PL 00240/5209R

02/03/2009

07/12/2011