Asda Thrush Relief Cream

Lloydspharmacy Antifungal Skin Cream

Lloydspharmacy Thrush Femme Cream

Clotrimazole 1% cream BP

Boots Antifungal Cream

Tesco Antifungal Cream

Morrisons Thrush Relief Cream

Clotrimazole B.P. 1% w/w

Cream

For the treatment of skin infections due to dermatophytes (e.g. trycophyton species), yeasts (e.g. candida species), moulds and other fungi. These include ringworm (tinea) infections, paronychia, pityriasis versicolor, erythrasma and intertrigo, as well as fungal nappy rash, candidal vulvitis and candidal balanitis.

Dosage:

Adult, children and elderly:

Apply to the affected area two or three times daily

Dermatophyte infections: treat for at least one month

Candida infections: treat for at least two weeks

Route of administration:

Directly applied to the affected area.

A physician should be consulted if symptoms do not improve within 7 days.

Known hypersensitivity to any of the components

The cream contains cetyl alcohol and stearyl alcohol, which may cause local skin reaction (e.g. contact dermatitis).

Pregnancy

Data on a large number of exposed pregnancies indicate no adverse effects of Clotrimazole on pregnancy or on the health of the foetus/newborn child. To date, no other relevant epidemiological data are available.

Clotrimazole can be used during pregnancy, but only under the supervision of a physician or midwife.

Breast-feeding

It is unknown whether clotrimazole is excreted in breast milk, so it should be given with caution to lactating mothers.

None known

As the listed undesirable effects are based on spontaneous reports, assigning accurate frequency of occurrence for each is not possible.

Immune system disorders: allergic reaction (syncope, hypotension, dyspnoea, urticaria)

Skin and subcutaneous tissue disorders: blisters, discomfort/pain, oedema, irritation, peeling/exfoliation, pruritus, rash, stinging/burning

ATC code: D01A C01

Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It also exhibits activity against Trichomonas, staphylococci, streptococci and Bacteroides. It has no effect on lactobacilli.

Mechanism of action

Clotrimazole acts against fungi by inhibiting ergosterol synthesis. Inhibition of ergosterol synthesis leads to structural and functional impairment of the cytoplasmic membrane.

Pharmacodynamic effects

Clotrimazole has a broad antimycotic spectrum of action in vitro and in vivo, which includes dermatophytes, yeasts, moulds, etc.

The mode of action of clotrimazole is fungistatic or fungicidal depending on the concentration of clotrimazole at the site of infection. In-vitro activity is limited to proliferating fungal elements; fungal spores are only slightly sensitive.

Primarily resistant variants of sensitive fungal species are very rare; the development of secondary resistance by sensitive fungi has so far only been observed in very isolated cases under therapeutic conditions.

Pharmacokinetic investigations after dermal application have shown that clotrimazole is minimally absorbed from the intact or inflamed skin into the human blood circulation. The resulting peak serum concentrations of clotrimazole were below the detection limit of 0.001 mcg/ml, suggesting that clotrimazole applied topically is unlikely to lead to measurable systemic effects or side effects.

There are no preclinical data of reference to the prescriber which are additional to the information included in other sections of the SPC.

Sorbitan stearate

Polysorbate 60

Cetyl Esters Wax

Stearyl Alcohol

Cetyl Alcohol

2-Octyldodecanol

Benzyl Alcohol

Purified Water

None known

36 months

None

Aluminium tube with polypropylene screw-on cap containing 20/30/50g of cream.

None

Teva UK Limited

Brampton Road

Hampden Park

Eastbourne

East Sussex

BN22 9AG

PL 00289/1490

27 January 1998 / 08 April 2003

21/02/2012