CONDITION | | ADULTS' DOSAGE (INCLUDING ELDERLY) | CHILDREN'S DOSAGE
( < 40 kg) | NOTES |
Dental procedures: prophylaxis for patients undergoing extraction, scaling or surgery involving gingival tissues and who have not received a penicillin in the previous month. (N.B. Patients with prosthetic heart valves should be referred to hospital - see below). | Patient not having general anaesthetic. | 3 g 'Amoxil' orally, 1 hour before procedure. A second dose may be given 6 hours later, if considered necessary. | 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure | Note 1. If prophylaxis with 'Amoxil' is given twice within one month, emergence of resistant streptococci is unlikely to be a problem. Alternative antibiotics are recommended if more frequent prophylaxis is required, or if the patient has received a course of treatment with a penicillin during the previous month. Note 2 To minimise pain on injection, 'Amoxil' may be given as two injections of 500 mg dissolved in sterile 1% lidocaime solution (see Administration). |
Patient having general anaesthetic: if oral antibiotics considered to be appropriate. | Initially 3 g 'Amoxil' orally 4 hours prior to anaesthesia, followed by 3 g orally (or 1 g IV or IM if oral dose not tolerated) as soon as possible after the operation. |
Patient having general anaesthetic: if oral antibiotics not appropriate. | 1 g 'Amoxil' IV or IM immediately before induction; with 500 mg orally, 6 hours later. |
Dental procedures: patients for whom referral to hospital is recommended: a) Patients to be given a general anaesthetic who have been given a penicillin in the previous month. b) Patients to be given a general anaesthetic who have a prosthetic heart valve. c) Patients who have had one or more attacks of endocarditis. | Initially: 1 g 'Amoxil' IV or IM with 120 mg gentamicin IV or IM immediately prior to anaesthesia (if given) or 15 minutes prior to dental procedure. Followed by (6 hours later): 500 mg 'Amoxil' orally. | 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure | See Note 2. Note 3. 'Amoxil' and gentamicin should not be mixed in the same syringe. Note 4. Please consult the appropriate data sheet for full prescribing information on gentamicin. |
Genitourinary Surgery or Instrumentation: prophylaxis for patients who have no urinary tract infection and who are to have genito-urinary surgery or instrumentation under general anaesthesia. In the case of Obstetric and Gynaecological Procedures
and Gastrointestinal Procedures– routine prophylaxis is recommended only for patients with prosthetic heart valves. | Initially: 1 g 'Amoxil' IV or IM with 120 mg gentamicin IV or IM, immediately before induction. Followed by (6 hours later): 500 mg 'Amoxil' orally or IV or IM according to clinical condition. | See Notes 2, 3 and 4 above. |
Surgery or Instrumentation of the Upper Respiratory Tract | Patients other than those with prosthetic heart valves. | 1 g 'Amoxil' IV or IM immediately before induction; 500 mg 'Amoxil' IV or IM 6 hours later. | 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure | See Note 2 above. Note 5. The second dose of 'Amoxil' may be administered orally as 'Amoxil' Syrup SF/DF. |
Patients with prosthetic heart valves. | Initially: 1 g 'Amoxil' IV or IM with 120 mg gentamicin IV or IM, immediately before induction; followed by (6 hours later) 500 mg 'Amoxil' IV or IM. | 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure | See Notes 2, 3, 4 and 5 above. |
