Bite and Sting Relief Antihistamine Cream

Cream.

P: For the symptomatic relief of insect bites and stings and nettle rash.

GSL: For the symptomatic relief of insect bites and stings and nettle stings.

P: For adults, children and the elderly: Rub gently on to the affected area sparingly two or three times each day for up to three days.

GSL: For adults, elderly and children 2 years of age and over: Rub gently on to the affected area sparingly two or three times each day for up to three days.

For topical application to the skin.

Hypersensitivity to any of the ingredients or other antihistamines.

Should not be applied to acute vesicular and exudative dermatoses or eczema.

P & GSL:

Do not apply to broken skin or eczema.

Not to be applied to large areas of skin.

If rash develops or gets worse stop using the product.

For external use only.

Keep all medicines out of the reach of children.

If symptoms do not go away, talk to your doctor.

In addition GSL:

Do not apply to sunburnt skin.

No clinically significant drug interactions expected.

The safety of this product during pregnancy and lactation has not been established. In view of the potential for systemic absorption through the skin, the product should not be used during these periods unless under medical supervision.

No adverse effects known.

Occasional local hypersensitivity reactions.

In cases of excessive application to the skin, sufficient absorption may occur to give rise to systemic adverse effects. Treatment should be symptomatic.

Mepyramine maleate is an H₁ receptor antagonist (antihistamine) of the ethylene diamine type. It diminishes or abolishes the effects of histamine in the body by competitive reversible blockade of histamine receptor sites on tissues.

Mepyramine maleate is readily absorbed through the skin, metabolised in the liver and excreted, mainly as metabolites in the urine.

There are no preclinical data of relevance to the prescriber which are additional to that already included.

White soft paraffin BP

Liquid paraffin Ph Eur

Anhydrous lanolin EP

Arlacel 83 HSE

Cetomacrogol 1000 BP

Cetostearyl alcohol Ph Eur

Citric acid monohydrate Ph Eur

Sodium citrate Ph Eur

Purified water Ph Eur

None known.

24 months.

Do not store above 25°C.

A collapsible internally lacquered aluminium tube with membrane seal fitted with a high density polyethylene cap.

Pack size

P: 25gm, 30gm.

GSL: 20g

Not applicable.

The Boots Company PLC

1 Thane Road West

Nottingham NG2 3AA

PL 00014/0440

Date of first authorisation: 28 September 1993

Date of last renewal: 12 November 2003

January 2005