| Section 2 removal of Ph Eur and correction of tablet to sachet
Section 4.2 addition of caution for use in elderly, and warning that product should be discontinued if pain gets worse or lasts more than 10 days, or if fever lasts more than 3 days
Section 4.3 all contra-indications with the exception of peptic ulcer, haemophilia and hypersensitivity to aspirin are new additions
Section 4.4 addition of first paragraph containing new special warnings and precautions including hypertension, renal and hepatic impairment, and warning to avoid excessive intake of caffeine
Section 4.5 all drug interactions with the exception of anticoagulants, methotrexate, oral hypoglycaemic agents and uricosuric agents are new additions
Section 4.6 amended from best avoided during late pregnancy and breast feeding to avoid during pregnancy and lactation, with relevant further information included
Section 4.8 complete revision of section
Section 4.9 revision of information relating to caffeine overdose, and management of overdose. Specifically removal of administration of activated charcoal in the management of overdose and addition of no specific antidote available.
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