| 4.2 Posology & Method of Administration: Not to be broken or crushed
4.3 Contraindications: Hepatic or renal failure; during the last trimester of pregnancy
4.4 Special Warnings & Precautions for Use: New sections on elevations of liver function tests; use in cardiac impairment, uncontrolled hypertension, congestive heart failure, established ischaemic heart disease, peripheral arterial disease, cerebrovascular disease, cirrhosis; renal effects; contraindication in patients with baseline creatine clearance less than 30ml/min (was 20ml/min); information on risk of GI bleeding, ulceration or perforation; risk of aseptic meningitis; precautions related to female infertility
4.5 Interaction with other medicinal products and other forms of interaction: Addition of hydantoin, sulphonamide or sulphonylurea, tacrolimus and zidovudine
4.6 Pregnancy and Lactation: Addition of further information; naproxen is contraindicated during the last trimester of pregnancy
4.8 Undesirable effects: Addition of several adverse events reported with naproxen and NSAIDs
4.9 Overdose: Addition of further information
5.2 & 5.3 Pharmacological Properties: Addition of further information
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