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Merck Sharp & Dohme Limited
Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU
Telephone: +44 (0)1992 467 272
Fax: +44 (0)1992 479 292
Medical Information e-mail: medicalinformationuk@merck.com

Before you contact this company: often several companies will market medicines with the same active ingredient. Please check that this is the correct company before contacting them. Why?
Summary of Product Characteristics last updated on the eMC: 26/06/2008
SPC Timoptol Unit Dose 0.25% and 0.5% w/v Eye Drops Solution

When a pharmaceutical company changes an SPC or PIL, a new version is published on the eMC. For each version, we show the dates it was published on the eMC and the reasons for change.

Updated on 26/06/2008 and displayed until Current
Reasons for adding or updating:
  • Change to section 4.5 - Interaction with other medicinal products and other forms of interaction
Date of revision of text on the SPC:   01-Feb-2008
Legal Category:   POM
Black Triangle (CHM):   NO

Free-text change information supplied by the pharmaceutical company


The only change is to section 4.5 'Interactions with medicinal products and other forms of interactions' where a statement on SSRIs has been added. See below:

Potentiated systemic beta-blockade (e.g. decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g. quinidine, SSRIs) and timolol. ,possibly because quinidine inhibits the metabolism of timolol via the P-450 enzyme, CYP2D6..
Updated on 27/04/2007 and displayed until 26/06/2008
Reasons for adding or updating:
  • Change to section 1 -Name of the Medicinal product
Date of revision of text on the SPC:   03/2007
Legal Category:   POM
Black Triangle (CHM):   NO

Free-text change information supplied by the pharmaceutical company
Section 1 Name of Product

Timoptol Unit Dose Ophthalmic Solution 0.25% & 0.5% will now be called Timoptol Unit Dose 0.25% & 0.5% w/v Eye Drops Solution
Updated on 10/06/2002 and displayed until 27/04/2007
Reasons for adding or updating:
  • Change to section 4.8 - Undesirable Effects
Updated on 16/08/2001 and displayed until 10/06/2002
Reasons for adding or updating:
  • Transferred from eMC version 1
Updated on 16/08/2001 and displayed until 16/08/2001
Reasons for adding or updating:
  • Transferred from eMC version 1
Updated on 18/04/2001 and displayed until 16/08/2001
Reasons for adding or updating:
  • No reasons supplied
Updated on 06/09/1999 and displayed until 18/04/2001
Reasons for adding or updating:
  • No reasons supplied

Active Ingredients/Generics

 
  timolol maleate